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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

23 Nov 2018

Abstract excerpt

Most triple negative breast cancers (TNBCs) are aggressively metastatic with a high degree of intra-tumoral heterogeneity (ITH), but how ITH contributes to metastasis is unclear. Here, clonal dynamics during metastasis were studied in vivo using two patient-derived xenograft (PDX) models established from the treatment-naive primary breast tumors of TNBC patients diagnosed with synchronous metastasis. Genomic...

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PMID: 30498242
DOI: 10.1038/s41467-018-07406-4

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