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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

7 Apr 2016

Abstract excerpt

To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling malignant, immune, stromal, and endothelial cells. Malignant cells within the same tumor displayed transcriptional heterogeneity associated with the cell cycle, spatial context, and a drug-resistance program. In particular, all tumors...

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PMID: 27124452
DOI: 10.1126/science.aad0501

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