Article

The breast cancer pro-metastatic phenotype requires concomitant hyper-activation of ECM remodeling and dsRNA-IFN1 signaling in rare clone cells

2022-07-16

Abstract excerpt

<h4>ABSTRACT</h4> The molecular determinants of breast cancer (BC) pro-metastatic phenotype are largely unknown. Here, we leveraged lentiviral barcoding coupled to single-cell RNA sequencing to trace clonal and transcriptional evolution during BC metastatization. We showed that metastases derive from rare pro-metastatic clones that are under-represented in primary tumors. Both low clonal-fitness and high metastat...

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Literature Corpus work: 9ca209bf-01f8-5636-8fad-db093461e7e3
DOI: 10.1101/2022.07.13.499961

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