Article

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

2023-08-27

Abstract excerpt

Somatic driver mutations, in genes such as FBXW7, have been discovered in phenotypically normal colonic tissue, however their role in cancer initiation remains elusive. Using normal and gene-edited patient-derived human colon organoids as models of early tumour evolution we observed that FBXW7-/- mutations exerted an epistatic effect on subsequent transcription depending on the mutational background of the cell. S...

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Identifiers and source

Literature Corpus work: 6b87d643-6009-539a-a45f-6a879abb89c2
DOI: 10.1101/2023.08.25.554836

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