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Article

Somatic Mutation: What Shapes the Mutational Landscape of Normal Epithelia?

Cancer discovery - 6 Jul 2022

Fowler Joanna C, Jones Philip H

Abstract excerpt

Epithelial stem cells accumulate mutations throughout life. Some of these mutants increase competitive fitness and may form clones that colonize the stem cell niche and persist to acquire further genome alterations. After a transient expansion, mutant stem cells must revert to homeostatic behavior so normal tissue architecture is maintained. Some positively selected mutants may promote cancer development, whereas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35397477
DOI: 10.1158/2159-8290.CD-22-0145
PMCID: PMC7613026

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