Article
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.
Gut - 1 Dec 2020
Yan Helen H N, Siu Hoi Cheong, Ho Siu Lun, Yue Sarah S K, Gao Yang, Tsui Wai Yin, Chan Dessy, Chan April S, Wong Jason W H, Man Alice H Y, Lee Bernard C H, Chan Annie S Y, Chan Anthony K W, Hui Ho Sang, Cheung Arthur K L, Law Wai Lun, Lo Oswens S H, Yuen Siu Tsan, Clevers Hans, Leung Suet Yi
Abstract excerpt
OBJECTIVE: Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs. DESIGN: We established paired cancer (n=32) and normal organoids (n=18) from 20 patients enriched in microsatellite-stable EOCRC. Exome and transcriptome analysis was performed. RESULTS:...
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