Article

Tissue-location specific transcription programs drive tumor initiation dependencies in colon cancer

2023-05-24

Abstract excerpt

<title>Abstract</title> <p>It is unknown why cancers of the same tissue-type but in anatomically distinct locations exhibit different molecular dependencies for tumorigenesis. Proximal and distal colon cancers (CC) exemplify such characteristics, with <italic>BRAF</italic><sup><italic>V600E</italic></sup> predominantly occurring in proximal CC along with increased DNA methylation phenotype. Using mouse colon orga...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40a7759e-af9c-57dd-b29a-71e172550e43
DOI: 10.21203/rs.3.rs-2846349/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue-location specific transcription programs drive tumor initiation dependencies in colon cancerDOI 10.21203/rs.3.rs-2846349/v1Read

Tissue-location-specific transcription programs drive tumor dependencies in colon cancerSemantic proximity Read

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancerSemantic proximity Read

Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical ImplicationsSemantic proximity Read

Identification of tumor initiating cells and early marker genes in normal colonic epithelium that lead to neoplastic transformationSemantic proximity Read

The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to <i>irinotecan</i> (CPT-11)Semantic proximity Read

Current understanding and clinical utility of miRNAs regulation of colon cancer stem cellsSemantic proximity Read

Temporal expression and functional analysis of long non‐coding RNA s in colorectal cancer initiationSemantic proximity Read

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanismsSemantic proximity Read

Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators <i>EGR2</i> and <i>SOX2</i> in TumorigenesisSemantic proximity Read

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiationSemantic proximity Read

A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.Semantic proximity Read

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolutionSemantic proximity Read