Article
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis.
EMBO molecular medicine - 11 Oct 2023
Brown Matthew, Leon Alicia, Kedzierska Katarzyna, Moore Charlotte, Belnoue-Davis Hayley L, Flach Susanne, Lydon John P, DeMayo Francesco J, Lewis Annabelle, Bosse Tjalling, Tomlinson Ian, Church David N
Abstract excerpt
High-risk endometrial cancer has poor prognosis and is increasing in incidence. However, understanding of the molecular mechanisms which drive this disease is limited. We used genetically engineered mouse models (GEMM) to determine the functional consequences of missense and loss of function mutations in Fbxw7, Pten and Tp53, which collectively occur in nearly 90% of high-risk endometrial cancers. We show that...
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