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Article

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation

31 Mar 2023

Abstract excerpt

Cell state plasticity is carefully regulated in adult epithelia to prevent cancer. The aberrant expansion of the normally restricted capability for cell state plasticity in neoplasia is poorly defined. Using genetically engineered and carcinogen-induced mouse models of intestinal neoplasia, we observed that impaired differentiation is a conserved event preceding cancer development. Single-cell RNA sequencing...

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PMID: 36989360
DOI: 10.1126/sciadv.adf0927

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