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Article

Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data.

Genome research - 1 Aug 2018

Fan Jean, Lee Hae-Ock, Lee Soohyun, Ryu Da-Eun, Lee Semin, Xue Catherine, Kim Seok Jin, Kim Kihyun, Barkas Nikolaos, Park Peter J, Park Woong-Yang, Kharchenko Peter V

Abstract excerpt

Characterization of intratumoral heterogeneity is critical to cancer therapy, as the presence of phenotypically diverse cell populations commonly fuels relapse and resistance to treatment. Although genetic variation is a well-studied source of intratumoral heterogeneity, the functional impact of most genetic alterations remains unclear. Even less understood is the relative importance of other factors influencing...

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PMID: 29898899
DOI: 10.1101/gr.228080.117
PMCID: PMC6071640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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