Article

Robust analysis of allele-specific copy number alterations from scRNA-seq data with XClone

2023-04-05

Abstract excerpt

Somatic copy number alterations (CNAs) are major mutations that contribute to the development and progression of various cancers. Despite a few computational methods proposed to detect CNAs from single-cell transcriptomic data, the technical sparsity of such data makes it challenging to identify allele-specific CNAs, particularly in complex clonal structures. In this study, we present a statistical method, XClone,...

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Literature Corpus work: d95014f3-95f1-5c07-acb6-bf1c25b6851e
DOI: 10.1101/2023.04.03.535352

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