Article

Accurate quantification of copy-number aberrations and whole-genome duplications in multi-sample tumor sequencing data

2018-12-17

Abstract excerpt

Copy-number aberrations (CNAs) and whole-genome duplications (WGDs) are frequent somatic mutations in cancer. Accurate quantification of these mutations from DNA sequencing of bulk tumor samples is complicated by varying tumor purity, admixture of multiple tumor clones with distinct mutations, and high aneuploidy. Standard methods for CNA inference analyze tumor samples individually, but recently DNA sequencing of...

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Literature Corpus work: 5ffdc841-36ac-56a4-b73b-f5b49e68a791
DOI: 10.1101/496174

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