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Article

Allele-specific transcriptional effects of subclonal copy number alterations enable genotype-phenotype mapping in cancer cells.

Nature communications - 20 Mar 2024

Shi Hongyu, Williams Marc J, Satas Gryte, Weiner Adam C, McPherson Andrew, Shah Sohrab P

Abstract excerpt

Subclonal copy number alterations are a prevalent feature in tumors with high chromosomal instability and result in heterogeneous cancer cell populations with distinct phenotypes. However, the extent to which subclonal copy number alterations contribute to clone-specific phenotypes remains poorly understood. We develop TreeAlign, which computationally integrates independently sampled single-cell DNA and RNA...

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Identifiers

PMID: 38509111
DOI: 10.1038/s41467-024-46710-0
PMCID: PMC10954741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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