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Article

Robust analysis of allele-specific copy number alterations from scRNA-seq data with XClone.

Nature communications - 6 Aug 2024

Huang Rongting, Huang Xianjie, Tong Yin, Yan Helen Y N, Leung Suet Yi, Stegle Oliver, Huang Yuanhua

Abstract excerpt

Somatic copy number alterations (CNAs) are major mutations that contribute to the development and progression of various cancers. Despite a few computational methods proposed to detect CNAs from single-cell transcriptomic data, the technical sparsity of such data makes it challenging to identify allele-specific CNAs, particularly in complex clonal structures. In this study, we present a statistical method,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39107346
DOI: 10.1038/s41467-024-51026-0
PMCID: PMC11303794

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