Article

p53 restoration suppresses retrotransposon-driven chromosomal instability through nonlinear let-7 feedback and stochastic burst control

2026-03-02

Abstract excerpt

Long-read sequencing has revealed that concurrent LINE-1 (L1) retrotransposition events on non-homologous chromosomes frequently generate reciprocal chromosomal translocations early in tumorigenesis, establishing retrotransposons as active drivers of structural genome evolution (1). Endogenous mechanisms that constrain L1-mediated chromosomal instability remain incompletely defined. p53 transcriptionally induces t...

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Literature Corpus work: d9823bd4-1ec7-5ea7-abb5-4fd418f9c91a
DOI: 10.64898/2026.02.27.708419

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