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Pangenome reference assemblies reveal the variation and recent activity of human LINE-1 retrotransposons

2026-05-16

Abstract excerpt

LINE-1 retrotransposons are the only autonomous mobile elements still active in human genomes and remain a potent source of mutation, genome remodeling, and disease risk. However, young, full-length, potentially active copies (the elements most likely to shape present-day genomes) have been largely inaccessible to population-scale analysis because they are long, repetitive, and poorly resolved by short-read sequen...

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Literature Corpus work
2bb01e06-541a-5080-9075-ce3be1314004
DOI
10.64898/2026.05.14.725010
Open publication

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Pangenome reference assemblies reveal the variation and recent activity of human LINE-1 retrotransposonsDOI 10.64898/2026.05.14.725010
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