Article

Repair outcomes after germline homing endonuclease cleavage in Anopheles gambiae inform the design of synthetic gene drives

2026-06-23

Abstract excerpt

Homing endonuclease genes spread by cleaving homologous chromosomes that lack the endonuclease cassette, after which repair from the endonuclease-containing chromosome converts the cut allele into a copy of the drive allele. This mechanism has provided a conceptual foundation for synthetic gene drive systems, including CRISPR-based drives, that represent promising strategies for the genetic control of insect pests...

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Literature Corpus work: 6b9f1475-5c68-5c97-8ee1-26e300127c05
DOI: 10.64898/2026.06.23.733901

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