Article

A CRISPR endonuclease gene drive reveals two distinct mechanisms of inheritance bias

2020-12-15

Abstract excerpt

<h4>ABSTRACT</h4> RNA guided CRISPR gene drives have shown the capability of biasing transgene inheritance in multiple species. Among these, homing endonuclease drives are the most developed. In this study, we report the functioning of sds3, bgcn , and nup50 expressed Cas9 in an Aedes aegypti homing split drive system targeting the white gene. We report their inheritance biasing capability, propensity for mat...

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Literature Corpus work: 5b2009af-cb52-5f8c-b8f3-b9f076623068
DOI: 10.1101/2020.12.15.421271

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