Back to search

Article

Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in <i>Aldh2</i> * <i>2</i> knock-in mice

2025-06-24

Abstract excerpt

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that detoxifies multiple aldehyde species in the body. The ALDH2*2 allele (E487K) is one of the most common gene polymorphisms in humans, resulting in dysfunction of its enzyme activity. This study investigated in vivo mechanism of acute liver injury caused by exposure to allyl alcohol (AA) using Aldh2*2 knock-in (KI) mice with the same amino acid repla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6ae97e2e-baf6-5681-b2f9-8a87012e30d7
DOI
10.1101/2025.06.18.660242
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in <i>Aldh2</i> * <i>2</i> knock-in miceDOI 10.1101/2025.06.18.660242
Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.Semantic proximity
Aldehyde dehydrogenase 2 mitigates acrolein-driven ferroptosis to preserve kidney function.Semantic proximity
ALDH2 DEFICIENCY INCREASES SUSCEPTIBILITY TO BINGE ALCOHOL-INDUCED GUT LEAKINESS, ENDOTOXEMIA, AND ACUTE LIVER INJURY IN MICE THROUGH THE GUT-LIVER AXISSemantic proximity
Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging miceSemantic proximity
Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.Semantic proximity
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.Semantic proximity
Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.Semantic proximity
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.Semantic proximity
Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2.Semantic proximity
Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.Semantic proximity
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.Semantic proximity
ALDH2 mutation promotes skeletal muscle atrophy in mice via accumulation of oxidative stress.Semantic proximity
Select a neighboring publication to make it the new centre.