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Article

Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2.

Cardiovascular research - 1 Jun 2018

Ueta Cintia Bagne, Campos Juliane Cruz, Albuquerque Rudá Prestes E, Lima Vanessa Morais, Disatnik Marie-Hélène, Sanchez Angélica Bianchini, Chen Che-Hong, de Medeiros Marisa Helena Gennari, Yang Wenjin, Mochly-Rosen Daria, Ferreira Julio Cesar Batista

Abstract excerpt

Aims: We previously demonstrated that acute ethanol administration protects the heart from ischaemia/reperfusion (I/R) injury thorough activation of aldehyde dehydrogenase 2 (ALDH2). Here, we characterized the role of acetaldehyde, an intermediate product from ethanol metabolism, and its metabolizing enzyme, ALDH2, in an ex vivo model of cardiac I/R injury. Methods and results: We used a combination of homozygous...

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Share to Acetaldehyde
Share to Aldehyde Dehydrogenase, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Share to Gene Knock-In Techniques

Share to Myocardial Infarction

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Source

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Identifiers

PMID: 29579152
DOI: 10.1093/cvr/cvy070
PMCID: PMC5967552

Genes

ALDH2

Variants

Provenance

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