Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.

doi:10.3109/15376510903401708

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Article

Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.

Toxicology mechanisms and methods - 1 Nov 2009

Yu Hsu-Sheng, Oyama Tsunehiro, Isse Toyohi, Kitakawa Kyoko, Ogawa Masanori, Pham Thi-Thu-Phuong, Kawamoto Toshihiro

Abstract excerpt

Acetaldehyde is an intermediate of ethanol oxidation. It covalently binds to DNA, and is known as a carcinogen. Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that oxidizes acetaldehyde. Approximately 45% of Chinese and Japanese individuals have the inactive ALDH2 genotypes (ALDH2*2/*2 and ALDH2*1/*2), and Aldh2 knockout mice appear to be a valid animal model for humans with inactive ALDH2. This review...

Topics

Acetaldehyde
Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial
Animals
Carcinogens
DNA Adducts
Ethanol
Genetic Predisposition to Disease
Humans
Inhalation Exposure
Mice
Mice, Knockout
Models, Animal

Source

Open in PubMed

Identifiers

PMID: 19874182
DOI: 10.3109/15376510903401708

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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