Article
ALDH2 mutation promotes skeletal muscle atrophy in mice via accumulation of oxidative stress.
Bone - 1 Jan 2021
Kobayashi Hiroki, Nakamura Satoshi, Sato Yuiko, Kobayashi Tami, Miyamoto Kana, Oya Akihito, Matsumoto Morio, Nakamura Masaya, Kanaji Arihiko, Miyamoto Takeshi
Abstract excerpt
Muscle atrophy is promoted by various factors including aging, immobilization, unloading and use of drugs such as steroids. However, genetic risk factors for muscle atrophy are less well known. Here, we show that a missense SNP in the ALDH2 gene, rs671 (ALDH2*2), a dominant negative mutation, promotes significant muscle atrophy in the ALDH2*2 mouse model, accompanied by decreased expression of anabolic and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.