Article
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2015
Jin Shengfang, Chen Jiang, Chen Lizao, Histen Gavin, Lin Zhizhong, Gross Stefan, Hixon Jeffrey, Chen Yue, Kung Charles, Chen Yiwei, Fu Yufei, Lu Yuxuan, Lin Hui, Cai Xiujun, Yang Hua, Cairns Rob A, Dorsch Marion, Su Shinsan M, Biller Scott, Mak Tak W, Cang Yong
Abstract excerpt
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) in the liver removes toxic aldehydes including acetaldehyde, an intermediate of ethanol metabolism. Nearly 40% of East Asians inherit an inactive ALDH2*2 variant, which has a lysine-for-glutamate substitution at position 487 (E487K), and show a characteristic alcohol flush reaction after drinking and a higher risk for gastrointestinal cancers. Here we report the...
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