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Article

Aldehyde dehydrogenase 2 mitigates acrolein-driven ferroptosis to preserve kidney function.

Environmental pollution (Barking, Essex : 1987) - 1 Feb 2026

Kuo Yu-Ming, Chung Shiu-Dong, Chang Jui-Ting, Yang Hui-Min, Lee Chieh-Chen, Lin Chih-Ching, Wang Hsiang-Tsui

Abstract excerpt

Acrolein, a highly reactive aldehyde generated endogenously through lipid peroxidation and exogenously from various environmental sources, is an important mediator of oxidative renal injury. Its accumulation in proximal tubular epithelial cells (PTECs) leads to mitochondrial dysfunction, oxidative stress, and cell death. Aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes; however, the common East...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41419041
DOI: 10.1016/j.envpol.2025.127555

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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