Article

Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging mice

2026-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Age-related diseases arise from prolonged exposure to genetic and/or environmental factors, ultimately leading to cumulative and irreversible degeneration of tissues and the organism as a whole. We previously reported that accumulation of mitochondrially-generated aldehydes (i.e., 4-hydroxynonenal and acetaldehyde) causes mitochondrial dysfunction and accelerates the progression of age-related d...

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Literature Corpus work: f9546404-cd58-5c14-8b77-6d3120b2a9e5
DOI: 10.64898/2026.05.25.727652

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