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Article

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.

Nature - 6 Jul 2011

Langevin Frédéric, Crossan Gerry P, Rosado Ivan V, Arends Mark J, Patel Ketan J

Abstract excerpt

Reactive aldehydes are common carcinogens. They are also by-products of several metabolic pathways and, without enzymatic catabolism, may accumulate and cause DNA damage. Ethanol, which is metabolised to acetaldehyde, is both carcinogenic and teratogenic in humans. Here we find that the Fanconi anaemia DNA repair pathway counteracts acetaldehyde-induced genotoxicity in mice. Our results show that the...

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Identifiers

PMID: 21734703
DOI: 10.1038/nature10192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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