Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.

Physiological reviews - 1 Jan 2014

Chen Che-Hong, Ferreira Julio Cesar Batista, Gross Eric R, Mochly-Rosen Daria

Abstract excerpt

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated. Although the human genome has 19 ALDH genes, one ALDH emerges as a particularly important enzyme in a variety of human pathologies. This ALDH, ALDH2, is located in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Alcohol Consumption and Health Effects
Share to Aldehyde Dehydrogenase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aldehyde Dehydrogenase, Mitochondrial

Share to ALDH2 gene

Share to Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24382882
DOI: 10.1152/physrev.00017.2013
PMCID: PMC3929114

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.PMID 24382882Read ↗

A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant.Semantic proximity Read ↗

Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.Semantic proximity Read ↗

The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatmentSemantic proximity Read ↗

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.Semantic proximity Read ↗

Advances in Factors Affecting ALDH2 Activity and its Mechanisms.Semantic proximity Read ↗

Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease PathogenesisSemantic proximity Read ↗

Analysis and update of the human aldehyde dehydrogenase (ALDH) gene familySemantic proximity Read ↗

Aldehyde dehydrogenase 2-associated metabolic abnormalities and cardiovascular diseases: current status, underlying mechanisms, and clinical recommendationsSemantic proximity Read ↗

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.Semantic proximity Read ↗

ALDH2 Enzyme Deficiency in Diabetic CardiomyopathySemantic proximity Read ↗

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.Semantic proximity Read ↗

ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.