Article

ALDH2 DEFICIENCY INCREASES SUSCEPTIBILITY TO BINGE ALCOHOL-INDUCED GUT LEAKINESS, ENDOTOXEMIA, AND ACUTE LIVER INJURY IN MICE THROUGH THE GUT-LIVER AXIS

2022-04-24

Abstract excerpt

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is the major enzyme responsible for metabolizing toxic acetaldehyde to acetate and acts as a protective or defensive protein against various disease states associated with alcohol used disorder (AUD), including alcoholic liver disease (ALD), and elevated oxidative stress. We hypothesized that Aldh2 -knockout (KO) mice are susceptible to binge alcohol-mediated liver i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e268fb32-d3be-5ff9-9ab1-dea6d390f275
DOI: 10.1101/2022.04.23.489282

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ALDH2 DEFICIENCY INCREASES SUSCEPTIBILITY TO BINGE ALCOHOL-INDUCED GUT LEAKINESS, ENDOTOXEMIA, AND ACUTE LIVER INJURY IN MICE THROUGH THE GUT-LIVER AXISDOI 10.1101/2022.04.23.489282Read

Alcohol and the mechanisms of liver diseaseSemantic proximity Read

A common East Asian-specific ALDH2 mutation causes obesity and insulin resistance: therapeutic effect of reducing toxic aldehydes by ALDH2 activationSemantic proximity Read

Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in <i>Aldh2</i> * <i>2</i> knock-in miceSemantic proximity Read

Aldehyde Dehydrogenase, Liver Disease and CancerSemantic proximity Read

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.Semantic proximity Read

Graphene Oxide Nanoparticles Mediated Protective Effect Against the Ethanol Induced Gut-Liver Axis by Targeting miRNA-203a and miRNA-122Semantic proximity Read

Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption.Semantic proximity Read

Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.Semantic proximity Read

Molecular Basis of Alcohol-Related Gastric and Colon CancerSemantic proximity Read

Host ALDH2 deficiency aggravates nonalcoholic steatohepatitis through gut-liver axisSemantic proximity Read

IDH2 deficiency exacerbates acetaminophen hepatotoxicity in mice via mitochondrial dysfunction-induced apoptosisSemantic proximity Read

Aldehyde dehydrogenase 2 deficiency significantly exacerbates tert-butyl alcohol-induced toxicity in mice.Semantic proximity Read