Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.

doi:10.1517/17425255.4.6.697

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Article

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.

Expert opinion on drug metabolism & toxicology - 1 Jun 2008

Marchitti Satori A, Brocker Chad, Stagos Dimitrios, Vasiliou Vasilis

Abstract excerpt

BACKGROUND: Aldehydes are highly reactive molecules. While several non-P450 enzyme systems participate in their metabolism, one of the most important is the aldehyde dehydrogenase (ALDH) superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation. OBJECTIVE: This article presents a review of what is currently known about each member of the human ALDH superfamily including the...

Topics

Aldehyde Dehydrogenase
Aldehydes
Gene Expression Regulation, Enzymologic
Humans
Isoenzymes
Metabolism, Inborn Errors
Mutation
Oxidation-Reduction
Substrate Specificity

Source

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Identifiers

PMID: 18611112
DOI: 10.1517/17425255.4.6.697
PMCID: PMC2658643

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