Article

Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation

2025-06-17

Abstract excerpt

Cellular senescence is a stable form of cell cycle arrest that contributes to aging and age-associated diseases through the secretion of inflammatory factors collectively known as the senescence-associated secretory phenotype (SASP). While senescence is driven by transcriptional and epigenetic changes, the contribution of higher-order genome organization remains poorly defined. Here, we present the highest-resolut...

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Literature Corpus work: 6a70a017-2544-5455-8e2c-38e7afd55790
DOI: 10.1101/2025.06.11.659151

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