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Article

The senescent cell epigenome

3 Nov 2018

Abstract excerpt

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory cytokine release in cells, caused by a variety of stresses. Recent work has convincingly linked the accumulation of senescent cells in aged tissues to a decline in health and a limit of lifespan, primarily through "inflammaging". Importantly, interventions that clear senescent cells have achieved marked improvements in...

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Share to Epigenetics and DNA Methylation
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PMID: 30391936
DOI: 10.18632/aging.101617

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