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Epigenetic Regulation of Cellular Senescence

15 Feb 2022

Abstract excerpt

Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease. How a cell transitions to a senescent state is multifactorial and often requires transcriptional regulation of multiple genes. Epigenetic alterations to DNA and chromatin are powerful regulators of genome architecture and...

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PMID: 35203320
DOI: 10.3390/cells11040672

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