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Article

The Histone Code of Senescence.

Cells - 18 Feb 2020

Paluvai Harikrishnareddy, Di Giorgio Eros, Brancolini Claudio

Abstract excerpt

Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes senescence is a pro-survival response to irreparable DNA damage. The maintenance of this prolonged condition requires the adaptation of the cells to an unfavorable, demanding and stressful microenvironment. This adaptation is orchestrated...

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Identifiers

PMID: 32085582
DOI: 10.3390/cells9020466
PMCID: PMC7072776

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