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The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression

24 Oct 2024

Abstract excerpt

Senescence and epigenetic alterations stand out as two well-characterized hallmarks of aging. When cells become senescent, they cease proliferation and release inflammatory molecules collectively termed the Senescence-Associated Secretory Phenotype (SASP). Senescence and SASP are implicated in numerous age-related diseases. Senescent cell nuclei undergo epigenetic reprogramming, which intricately regulates SASP...

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Share to Epigenetics and DNA Methylation
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 39448585
DOI: 10.1038/s41514-024-00172-2

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