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Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells.

Aging cell - 1 Jan 2026

Zhang Ge, Zhang Wei, Wang Changxu, Jiang Zhirui, Xu Qixia, Li Haipeng, Kirkland James L, Wei Gang, Sun Yu

Abstract excerpt

Cellular senescence is a fundamental biological process contributing to aging, often accompanied by extensive chromatin remodeling. Dynamic alterations of three-dimensional (3D) genomic spatial structure, driven by chromatin reorganization, play a critical role in cell fate determination, but their relevance in therapy-induced senescence (TIS) remains underexplored. Here, we perform an integrative multi-omics...

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PMID: 41493135
DOI: 10.1111/acel.70366
PMCID: PMC12771664

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