Article

Topological demarcation by HMGB2 is disrupted early upon senescence entry across cell types and induces CTCF clustering

2017-04-14

Abstract excerpt

Ageing-relevant processes, like cellular senescence, are characterized by complex, often stochastic, events giving rise to heterogeneous cell populations. We hypothesized that entry into senescence of different primary human cells can be triggered by one early molecular event affecting the spatial organization of chromosomes. To test this, we combined whole-genome chromosome conformation capture, population and si...

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Literature Corpus work: 9a3fcda2-11f2-5076-9edd-4c2b5caa934b
DOI: 10.1101/127522

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