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Article

Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

3 Mar 2015

Abstract excerpt

BACKGROUND: Primary cells enter replicative senescence after a limited number of cell divisions. This process needs to be considered in cell culture experiments, and it is particularly important for regenerative medicine. Replicative senescence is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains...

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PMID: 25763115
DOI: 10.1186/s13148-015-0057-5

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