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Interrogating the regulatory epigenome of cellular senescence

31 Aug 2025

Abstract excerpt

Chromatin, the spatial organizer of genomic DNA, is hierarchically folded into higher-order structures to facilitate DNA compaction, enabling genome surveillance. Understanding the organization and function of the three-dimensional (3D) genome is critical to profile chromatin accessibility and functional interactions that govern gene regulation across multiple biological processes, including aging and one of its...

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Share to Epigenetics and DNA Methylation
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PMID: 40886198
DOI: 10.1007/s00018-025-05848-w

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