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Dynamic 3D genome reorganization during senescence: defining cell states through chromatin

18 Aug 2023

Abstract excerpt

Cellular senescence, a cell state characterized by growth arrest and insensitivity to growth stimulatory hormones, is accompanied by a massive change in chromatin organization. Senescence can be induced by a range of physiological signals and pathological stresses and was originally thought to be an irreversible state, implicated in normal development, wound healing, tumor suppression and aging. Recently cellular...

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PMID: 37596440
DOI: 10.1038/s41418-023-01197-y

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