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Article

TFAP2C regulates transcription in human naive pluripotency by opening enhancers.

Nature cell biology - 1 May 2018

Pastor William A, Liu Wanlu, Chen Di, Ho Jamie, Kim Rachel, Hunt Timothy J, Lukianchikov Anastasia, Liu Xiaodong, Polo Jose M, Jacobsen Steven E, Clark Amander T

Abstract excerpt

Naive and primed pluripotent human embryonic stem cells bear transcriptional similarity to pre- and post-implantation epiblast and thus constitute a developmental model for understanding the pluripotent stages in human embryo development. To identify new transcription factors that differentially regulate the unique pluripotent stages, we mapped open chromatin using ATAC-seq and found enrichment of the activator...

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Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Source

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Identifiers

PMID: 29695788
DOI: 10.1038/s41556-018-0089-0
PMCID: PMC5926822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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