Article

Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

2023-03-09

Abstract excerpt

<title>Abstract</title> <p>The normally antiviral enzyme APOBEC3A<sup>1-4</sup> is an endogenous mutagen in many different human cancers<sup>5-7</sup>, where it becomes hijacked to fuel tumor evolvability. APOBEC3A’s single-stranded DNA C-to-U editing activity<sup>1-8</sup> results in multiple mutagenic outcomes including signature single-base substitution mutations (isolated and clustered), DNA breakage, and lar...

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Literature Corpus work: 69d27607-d73d-5975-bda1-9ccc2ac81293
DOI: 10.21203/rs.3.rs-2598101/v1

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