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Article

Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

2023-02-17

Abstract excerpt

<h4>ABSTRACT</h4> The normally antiviral enzyme APOBEC3A 1-4 is an endogenous mutagen in many different human cancers 5-7 , where it becomes hijacked to fuel tumor evolvability. APOBEC3A’s single-stranded DNA C-to-U editing activity 1, 8 results in multiple mutagenic outcomes including signature single-base substitution mutations (isolated and clustered), DNA breakage, and larger-scale chromosomal aberrations...

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Identifiers and source

Literature Corpus work
299ce2f3-bdf7-5f91-8626-f6825b016b66
DOI
10.1101/2023.02.17.528918
Open publication

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