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Structure-Guided Design of a Potent and Specific Inhibitor against the Genomic Mutator APOBEC3A

8 Dec 2022

Abstract excerpt

Nucleic acid structure plays a critical role in governing the selectivity of DNA- and RNA-modifying enzymes. In the case of the APOBEC3 family of cytidine deaminases, these enzymes catalyze the conversion of cytosine (C) to uracil (U) in single-stranded DNA, primarily in the context of innate immunity. DNA deamination can also have pathological consequences, accelerating the evolution of viral genomes or, when...

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PMID: 36475588
DOI: 10.1021/acschembio.2c00796

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