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Article

Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties.

Nucleic acids research - 1 Jan 2014

Mitra Mithun, Hercík Kamil, Byeon In-Ja L, Ahn Jinwoo, Hill Shawn, Hinchee-Rodriguez Kathyrn, Singer Dustin, Byeon Chang-Hyeock, Charlton Lisa M, Nam Gabriel, Heidecker Gisela, Gronenborn Angela M, Levin Judith G

Abstract excerpt

Human APOBEC3A (A3A) is a single-domain cytidine deaminase that converts deoxycytidine residues to deoxyuridine in single-stranded DNA (ssDNA). It inhibits a wide range of viruses and endogenous retroelements such as LINE-1, but it can also edit genomic DNA, which may play a role in carcinogenesis. Here, we extend our recent findings on the NMR structure of A3A and report structural, biochemical and cell-based...

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Identifiers

PMID: 24163103
DOI: 10.1093/nar/gkt945
PMCID: PMC3902935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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