Article

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

2019-01-07

Abstract excerpt

The single-stranded DNA cytosine deaminase APOBEC3B (A3B) functions in innate immunity against viruses, but is also strongly implicated in eliciting mutations in cancer genomes. Because of the critical role of A3B in promoting virus and tumor evolution, small molecule inhibitors are desirable. However, there is no reported structure for any of the APOBEC3-family enzymes in complex with a small molecule bound in th...

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Literature Corpus work: 6c0fb05c-cf6e-5122-9972-d3c84d021250
DOI: 10.1101/513366

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