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Article

Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes.

Nature communications - 18 Mar 2024

Sanchez Ambrocio, Ortega Pedro, Sakhtemani Ramin, Manjunath Lavanya, Oh Sunwoo, Bournique Elodie, Becker Alexandrea, Kim Kyumin, Durfee Cameron, Temiz Nuri Alpay, Chen Xiaojiang S, Harris Reuben S, Lawrence Michael S, Buisson Rémi

Abstract excerpt

Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially targets single-stranded DNAs, with a noted affinity for DNA regions that adopt stem-loop secondary structures. However, the detailed substrate preferences of APOBEC3A and APOBEC3B have not been fully established, and the specific influence of the...

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Identifiers

PMID: 38499542
DOI: 10.1038/s41467-024-45909-5
PMCID: PMC10948877

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