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Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

11 Oct 2023

Abstract excerpt

The normally antiviral enzyme APOBEC3A is an endogenous mutagen in human cancer. Its single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including signature single-base substitution mutations (isolated and clustered), DNA breakage, and larger-scale chromosomal aberrations. APOBEC3A inhibitors may therefore comprise a unique class of anti-cancer agents that work by blocking...

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PMID: 37821454
DOI: 10.1038/s41467-023-42174-w

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