Article
Defining the genome-wide mutagenic impact of APOBEC3 enzymes.
Methods in enzymology - 1 Jan 2025
Németh Eszter, DeWeerd Rachel A, Green Abby M, Szüts Dávid
Abstract excerpt
Somatic mutations drive cancer initiation and tumor evolution. Therefore, the etiology of mutagenesis in cancer is important to preventative and treatment strategies. Somatic mutagenesis in cancer is a multifactorial process and includes both endogenous and exogenous sources of mutations. One recently recognized source of mutagenesis in cancer is the innate immune APOBEC3 family of enzymes, which catalyze...
Read the complete abstract on PubMedTopics
- Humans
- Mutagenesis
- Neoplasms
- Cytidine Deaminase
- APOBEC Deaminases
- Cytosine Deaminase
- Mutation