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Article

Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer.

Nature genetics - 1 Nov 2022

Petljak Mia, Green Abby M, Maciejowski John, Weitzman Matthew D

Abstract excerpt

Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC)3 cytosine deaminase activity have been found in over half of cancer types, including some therapy-resistant and metastatic tumors. Driver mutations can occur in APOBEC3-favored sequence contexts, suggesting that mutagenesis by APOBEC3 enzymes may drive cancer evolution. The APOBEC3-mediated signatures...

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Identifiers

PMID: 36280735
DOI: 10.1038/s41588-022-01196-8
PMCID: PMC9700387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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