Article

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

2021-08-31

Abstract excerpt

The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein implicated in cancer. However, its substrates in cells are not fully delineated. Here, APOBEC3B proteomics reveal interactions with a surprising number of R-loop factors. Biochemical experiments show APOBEC3B binding to R-loops in human cells and in vitro . Genetic experiments demonstrate R-loop increases in cells lacking APOBEC...

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Identifiers and source

Literature Corpus work: 8cefcc21-5013-5b69-b9ea-026b988d8f13
DOI: 10.1101/2021.08.30.458235

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